New opportunity for serotonin receptor agonists
نویسندگان
چکیده
منابع مشابه
Detection of new biased agonists for the serotonin 5-HT2A receptor: modeling and experimental validation.
Detection of biased agonists for the serotonin 5-HT2A receptor can guide the discovery of safer and more efficient antipsychotic drugs. However, the rational design of such drugs has been hampered by the difficulty detecting the impact of small structural changes on signaling bias. To overcome these difficulties, we characterized the dynamics of ligand-receptor interactions of known biased and ...
متن کاملDetection of New Biased Agonists for the Serotonin 5-HT2A Receptor: Modeling and Experimental Validation s
Detection of biased agonists for the serotonin 5-HT2A receptor can guide the discovery of safer and more efficient antipsychotic drugs. However, the rational design of such drugs has been hampered by the difficulty detecting the impact of small structural changes on signaling bias. To overcome these difficulties, we characterized the dynamics of ligand-receptor interactions of known biased and ...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2008
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd2492